Comparative Efficacy of Pharmacological Interventions for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating urological condition affecting approximately 2-10% of men globally, with a substantial impact on quality of life, productivity, and healthcare utilization. Despite the availability of multiple pharmacological options, their comparative efficacy remains uncertain. This meta-analysis evaluated the efficacy of pharmacological interventions for CP/CPPS based on the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI).

Methods

A systematic search of PubMed, Scopus, ScienceDirect, and Google Scholar was conducted from database inception to January 2025 for randomized controlled trials (RCTs) comparing pharmacological therapies with placebo. The primary outcome was a mean reduction in

SUBMITTER: Alshahrani S 

PROVIDER: S-EPMC12652971 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature