Antioxidant Supplementation with ProCloSupp Protects Against Renal Toxicity of Atypical Antipsychotics in Rats: Implications for Safer Treatment Strategies.

ABSTRACT: Atypical antipsychotics (AAP), including clozapine (Clo), aripiprazole (Ari), and risperidone (Ris), are widely used in psychiatry but can lead to kidney damage due to oxidative stress. This study investigated whether dietary supplementation with selected antioxidants-ellagic acid, vitamin C, zinc, and seleno-methionine (SeMet) in fish oil, formulated as the composite product "ProCloSupp" (PCS)-can mitigate the oxidative damage induced by subchronic administration of AAP. Rats were treated with each antipsychotic for 28 days, with PCS added in the last 14 days. The kidney tissue was examined histologically and by determining the activities of antioxidant enzymes (copper, zinc and manganese superoxide dismutase-CuZn SOD and Mn SOD, catalase-CAT, glutathione peroxidase-GPx, glutathione reduc

SUBMITTER: Grahovac T 

PROVIDER: S-EPMC12653033 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature