Refracture and Mortality Following Surgical Management of Osteoporotic Vertebral Fractures: A Systematic Review and Meta-Analysis with Patient-Level Survival Modeling.

ABSTRACT: Background/Objectives: Osteoporotic vertebral fractures (OVFs) are a growing global health burden, often managed surgically with vertebroplasty or kyphoplasty. However, long-term outcomes such as refracture and mortality remain poorly characterized across heterogeneous studies. The study aims to determine the pooled rates of refracture and mortality following surgical treatment of OVFs, and to identify clinical and procedural predictors of these outcomes using meta-regression and reconstructed survival analysis. Methods: This systematic review and meta-analysis adhered to PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched up to 15 April 2025. Studies reporting refracture or mortality outcomes after surgical intervention for OVFs in adults were included.

SUBMITTER: Ghandour M 

PROVIDER: S-EPMC12653041 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature