Comprehensive Echocardiographic Assessment in Moderate Aortic Stenosis with Preserved Ejection Fraction Using Two-Dimensional Speckle-Tracking Echocardiography: Association with Functional Capacity.

ABSTRACT: Background/Objectives: Moderate aortic stenosis (AS) with preserved ejection fraction (EF) is common, yet risk stratification remains challenging. Cardiopulmonary exercise testing (CPET) and myocardial mechanics analysis may identify subclinical dysfunction and impaired functional capacity. To evaluate the relationship between functional capacity (by % predicted peak VO₂), ventilatory efficiency (VE/VCO₂ slope), and myocardial mechanics (speckle tracking echocardiography-STE), and myocardial work (MW) indices) in moderate AS with preserved EF. Methods: We prospectively enrolled 107 patients with moderate AS (AVA 1.0-1.5 cm²; mean gradient 20-40 mmHg; EF ≥ 50%). Functional capacity was classified as preserved (≥83% predicted VO₂) or

SUBMITTER: Petrovic O 

PROVIDER: S-EPMC12653056 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature