White Matter Integrity of the Corpus Callosum Mediates the Association Between Aging and Skin Condition.

ABSTRACT: This study examines whether white matter integrity mediates the link between psychological stress and skin aging. This cross-sectional study included 92 healthy Japanese adults (aged 22-62 years) who underwent diffusion tensor imaging to obtain Fractional Anisotropy Brain Healthcare Quotients (FA-BHQs) for major white matter tracts, while skin aging was assessed using Motion Scan Technology. Correlation analyses revealed significant associations among stress, skin aging, and FA-BHQ in the corpus callosum (CC) and internal capsule (IC). Mediation analyses suggested, at the statistical level, a potential that the CC fully mediates the association between stress and skin aging. These findings suggest a relationship between interhemispheric white matter integrity, psychological stress, and ski

SUBMITTER: Yuan D 

PROVIDER: S-EPMC12653096 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature