Senolytic Treatment Improves Responsiveness to Mechanical Loading in the Skeleton of Aged Mice.

ABSTRACT: Aging plays a major role in the development of numerous chronic diseases, one of which is a marked decline in skeletal health. Beyond diminishing bone mass and strength, mammals of advanced age experience a decline in skeletal mechanotransduction-that is, the ability of the skeleton to respond adaptively to mechanical perturbation. One possibility for the loss of mechanotransduction in bone with aging is an age-associated increase in the population density of senescent cells-those cells that have undergone irreversible cell cycle arrest, resistance to apoptosis, and production of a modified secretome (the SASP) that has damaging effects to nearby healthy (non-senescent) cells. We investigated whether the presence of senescent cells might drive some of the diminished mechanical response obs

SUBMITTER: Cunningham CJ 

PROVIDER: S-EPMC12653123 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature