Silent Persistence: Molecular Evidence of Clonal Transmission in Fluconazole-Resistant <i>Candida parapsilosis</i> Hospital Outbreaks over Decades.

ABSTRACT: Fluconazole-resistant Candida parapsilosis has emerged as a significant nosocomial pathogen, contributing to extensive outbreaks with severe clinical implications. Despite increasing evidence of clonal transmission, the genetic mechanisms that facilitate the persistence of hospital reservoirs remain inadequately characterized. We aimed to characterise the long-term molecular epidemiology of fluconazole-resistant Candida parapsilosis bloodstream isolates (n = 47) collected between 1997 and 2019 at a tertiary centre. All isolates underwent microsatellite analysis using three polymorphic markers (CP1, CP4, B5). Genetic diversity, temporal distribution, and clonal relationships were assessed through phylogenetic analysis and discriminatory power calculations. Microsatellite analy

SUBMITTER: Semet C 

PROVIDER: S-EPMC12653143 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature