Gene Expression Profiling Provides an Improved Characterization of <i>CD79B</i>-Mutated Diffuse Large B-Cell Lymphomas.

ABSTRACT: Background and Objectives: Diffuse large B-cell lymphomas (DLBCLs) are heterogeneous neoplasms. CD79B and MYD88 mutations are associated with the activated B-cell-like (ABC) subtype of DLBCL and often co-occur and lead to constitutive activation of the NF-κB pathway. Several different genetic classifications to date have recognized CD79B- and MYD88-mutated DLBCLs as a unique subtype with poor response to therapy and unfavorable survival. However, little is known about gene expression in DLBCLs with mutated CD79B (and MYD88) in comparison to their wild type counterparts. The objective of this study was to compare the gene expression in DLBCLs according to their CD79B mutational status. Methods: A total of 48 primary, treatment-n

SUBMITTER: Grossmann L 

PROVIDER: S-EPMC12653173 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature