Early Detection of Acute Kidney Injury After Congenital Heart Surgery-Using Urine Proteomics to Identify New Biomarker Candidates: A Prospective Clinical Study.

ABSTRACT: Background: Acute kidney injury (AKI) is a frequent complication following congenital heart surgery and is associated with increased morbidity and mortality. Early recognition is crucial, yet standard clinical biomarkers result in delayed detection. Urine, which can be collected non-invasively, offers unique insights into kidney function and systemic responses. Methods: This prospective clinical study aimed to identify novel urinary biomarkers for the early detection of AKI, using high-accuracy proteome profiling. Patients with congenital heart disease undergoing cardiac surgery at Deutsches Herzzentrum der Charité were included in the study. Urine samples were collected at four timepoints: preoperatively and immediately postoperatively, and then again at six and 24 h post-su

SUBMITTER: Seiler R 

PROVIDER: S-EPMC12653219 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature