Long-Term Outcomes of Nephron-Sparing Versus Radical Nephrectomy in Stage 4 Chronic Kidney Disease.

ABSTRACT: Background: Partial nephrectomy (PN) and radical nephrectomy (RN) are surgical options for localized renal cell carcinoma; however, PN is p referred for preserving renal function in patients with chronic kidney disease (CKD). This study compares the risks of end-stage renal disease (ESRD), hemodialysis, and cardiovascular complications between PN and RN in patients with stable stage 4 CKD, with a further focus on postoperative electrolyte imbalances as outcome predictors. Methods: This retrospective cohort study used TriNetX data (between 2005 and 2023). Patients with stable stage 4 CKD undergoing nephron-sparing procedures or RN were included. Propensity-score matching ensured balanced baseline characteristics. The analyzed outcomes included renal function, hemodialysis, ele

SUBMITTER: Chang NW 

PROVIDER: S-EPMC12653262 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature