Structural and Functional Insights into Methuselah Genes of <i>Plutella xylostella (Lepidoptera: Plutellidae)</i>: Evolutionary Adaptations and Their Responses to Chlorantraniliprole.

ABSTRACT: G protein-coupled receptors (GPCRs) are considered the largest and most variable family of transmembrane receptors regulating physiological processes such as toxicological responses and insecticide resistance development. The present study investigated the responses of Methuselah (Mth), belonging to GPCR family B in the Diamondback Moth (DBM), Plutella xylostella, to chlorantraniliprole (CAP). Genome-wide identification and phylogenetic analysis of Pxmth genes revealed their evolutionary relationships and functional classifications. Expression profiling demonstrated significant overexpression of Pxmth2 in the CAP-resistant strain. Additionally, the tertiary and secondary structures of Pxmth2 were characterized, providing insights into its functional role.

SUBMITTER: Zolfaghari M 

PROVIDER: S-EPMC12653341 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature