The Epigenetic Landscape of Borderline Personality Disorder: Insights from a Systematic Review.

ABSTRACT: Background/Objectives: Borderline personality disorder (BPD) is a serious psychiatric condition characterized by affective instability, impulsivity, and self-harming behaviors. Increasing evidence suggests that epigenetic mechanisms, especially DNA methylation, may mediate the interaction between genetic susceptibility and adverse environmental factors. This systematic review aimed to synthesize available findings on DNA methylation in BPD, including candidate gene studies and epigenome-wide association studies (EWAS). Methods: We conducted a systematic search of PubMed, Embase, and Scopus databases following PRISMA guidelines. Eligible studies (N = 19) included original research examining DNA methylation in individuals with BPD, assessed either through candidate gene

SUBMITTER: Dawidowski B 

PROVIDER: S-EPMC12653379 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature