Two New Chromone Derivatives from a Marine Algicolous Fungus <i>Aspergillus versicolor</i> GXIMD 02518 and Their Osteoclastogenesis Inhibitory Activity.

ABSTRACT: Two new chromone derivatives, cnidimols I and J (1 and 2), together with ten known aromatic derivatives (3-12), were isolated from the Beibu Gulf algicolous fungus Aspergillus versicolor GXIMD 02518. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. The absolute configurations of 1 and 2 were accomplished by ECD calculations and X-ray diffraction analysis. Compound 1 was obtained as a pair of enantiomers, which were separated by chiral-phase HPLC analysis. Notably, 3,7-dihydroxy-1,9-dimethyldibenzofuran (6) displayed significant inhibition in LPS-induced NF-κB luciferase activity in RAW 264.7 macrophages, which further inhibited RANKL-induced osteoclast differentiation with

SUBMITTER: Qi X 

PROVIDER: S-EPMC12653716 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature