The Anti-Inflammatory and Skin Barrier Function Recovery Effects of <i>Carica papaya</i> Peel in Mice with Contact Dermatitis.

ABSTRACT: With growing concerns over the safety of synthetic substances, the development of plant-derived alternatives with minimal adverse effects has gained significant attention. Carica papaya L. peel contains a rich profile of bioactive compounds, including papain, flavonoids, and vitamin C, which exhibit potent antioxidant and anti-inflammatory properties. This study aimed to evaluate the effects of an ethanol extract of C. papaya peel (EECP) on inflammation and skin barrier dysfunction in a mouse model of contact dermatitis (CD) induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). Mice were treated by applying EECP at three different levels (60, 80, and 600 μg) to dorsal skin for six days. Skin lesion severity, skin color, skin barrier function (SBF, as indicated by water content

SUBMITTER: Park S 

PROVIDER: S-EPMC12653787 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature