Mitral Valve Surgery with and Without Mitral Annular Disjunction: A Meta-Analysis.

ABSTRACT:

Background/objectives

Despite growing awareness of mitral annular disjunction's (MAD) clinical significance, robust data regarding the outcomes of surgical interventions on MAD remain sparse. This meta-analysis aims to systematically evaluate the current evidence on the efficacy and safety of mitral valve (MV) surgery in patients with MAD.

Methods

A systematic review was conducted from inception until May 2025 for studies comparing patients undergoing MV surgery with and without MAD and was registered in PROSPERO: CRD42025649821.

Results

Patients with MAD were generally younger (59.3 ± 5.0 vs. 63.4 ± 2.2 years, standardized mean difference: -0.3073), had fewer comorbidities but more complex valve lesions (41.0% vs. 13.7%, risk difference: 0.2627) compared to those wit

SUBMITTER: Baudo M 

PROVIDER: S-EPMC12653801 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature