Diagnostic Utility of Monocyte Distribution Width for Early Sepsis Detection in Cancer-Enriched Emergency Cohort.

ABSTRACT: Background: Timely recognition of sepsis remains a critical clinical challenge, particularly in cancer patients, who are at higher risk due to immunosuppression. Monocyte distribution width (MDW) has emerged as a biomarker with potential utility in the early detection of sepsis. Methods: This retrospective study analyzed 1167 patients who presented to the emergency department of a cancer specialty hospital in Republic of Korea. Patients were classified according to Sepsis-2 and Sepsis-3 criteria, and the diagnostic performance of MDW was compared with conventional biomarkers, including C-reactive protein (CRP) and procalcitonin (PCT). Subgroup analyses were conducted based on malignancy status, leukopenia, and initial signs of infection. Additionally, turnaround times (TATs)

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC12653850 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature