Causal Effects of Plasma Metabolites on Leukemia: A Mendelian Randomization Study.

ABSTRACT: Background: Leukemia comprises heterogeneous hematologic malignancies, and whether circulating metabolites contribute causally to subtype-specific risk remains uncertain. Objectives: The aim of this study was to assess the causal effects of plasma metabolites for acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Methods: A two-sample Mendelian randomization (MR) using summary-level genome-wide association study statistics was conducted. For each metabolite, a single variant showing the strongest association with the metabolite that had the largest variance explained (R²) among the independent genome-wide significant (p < 5 × 10^-8) SNPs assigned to effect

SUBMITTER: Huang C 

PROVIDER: S-EPMC12654070 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature