Effect of High-Temperature Stress on Fatty Acid Composition and Undecylprodiginine Biosynthesis in <i>Streptomyces coelicolor</i> M511.

ABSTRACT: Actinomycetes are a representative group of bacteria that inhabit soil; in particular, Streptomyces coelicolor M511 produces actinorhodin and undecylprodiginine. Among them, undecylprodiginine has antibiotic and immunosuppression activity and is a secondary metabolite with high potential applications in biotechnological and pharmaceutical fields. High temperature stress (37 °C) reduced the biosynthesis of undecylprodiginine and induced specific branched chain alkylprodiginine derivatives, compared with the optimal growth temperature (30 °C). Also, the stress stimulated the synthesis of straight-chain FA for enhancing membrane rigidity. The inhibition of undecylprodiginine biosynthesis under high temperature stress seems to be induced by the heat sensitivity of the RedP enzyme, and t

SUBMITTER: Han Y 

PROVIDER: S-EPMC12654105 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature