Montagnulans A-D with Anti-Osteoclastogenic Activity from the Marine Fungus <i>Montagnula</i> sp. GXIMD 02514.

ABSTRACT: Four novel tetramic acid compounds, montagnulans A-D (1-4), were obtained from the Beibu Gulf coral-associated fungus Montagnula sp. GXIMD 02514. Their structures were determined by comprehensive physicochemical and spectroscopic data interpretation. The absolute configurations were accomplished by ECD calculations. Structurally, compounds 1-4 were rare leucine-derived tetramic acids bearing an ethyl (1-3) or hexylenic alcohol (4) side chain and a pyranone ring at C-3 of the 2,4-pyrrolidinedione core. Compound 1 exhibited inhibition of lipopolysaccharide (LPS)-induced NF-κB in RAW 264.7 macrophages at 20 μM, which further inhibited RANKL-induced osteoclast differentiation without cytotoxicity in bone marrow macrophages c

SUBMITTER: Lin M 

PROVIDER: S-EPMC12654181 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature