Harnessing Metabolomics to Advance Nutrition-Based Therapeutics for Inflammation: A Systematic Review of Randomized Clinical Trials.

ABSTRACT:

Background/objectives

The association between plasma metabolites derived from dietary substrates and inflammatory processes remains underexplored, despite its potential relevance in the prevention of non-communicable diseases. This systematic review aimed to examine the relationship between blood metabolites and the modulation of inflammatory biomarkers.

Methods

A total of 25 randomized controlled trials, published between 2019 and 2024, were included from an initial pool of 111 records. These studies investigated the effects of dietary patterns, specific food groups, or nutritional supplements on the human metabolome and their potential links to inflammation.

Results

Metabolomic analyses were predominantly performed using mass spectrometry (MS)-based platforms (17 ou

SUBMITTER: Carlino B 

PROVIDER: S-EPMC12654429 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature