Molecular Epidemiology of <i>Mycobacterium tuberculosis</i> in Mexico.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis, continues to be a leading cause of morbidity and mortality in Mexico, with more than 20,000 new cases annually and a rising proportion of drug-resistant strains. This work addresses the molecular epidemiology of TB in the Mexican context, emphasizing its role in understanding transmission, genetic diversity, and resistance mechanisms. To achieve this, we reviewed molecular typing approaches including spoligotyping, Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR) analysis, and whole-genome sequencing (WGS), which have been applied to characterize circulating lineages and identify drug-resistance-associated mutations. The results indicate that the Euro-American lineage (L4) predominates acros

SUBMITTER: Rodriguez-Martinez LM 

PROVIDER: S-EPMC12654501 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature