Metastatic Patterns of Malignant Germ Cell Tumors Vary by Histologic Subtype and Primary Site.

ABSTRACT: Background and Objectives: Malignant germ cell tumors (GCTs) are rare but clinically significant neoplasms arising in gonadal and extragonadal sites. Malignant GCTs, divided into seminomatous and non-seminomatous subtypes, show diverse biological behavior. Although molecular studies have advanced understanding of their origins and genetic features, little is known about metastatic patterns due to their rarity and generally favorable outcomes. This study aimed to describe metastatic patterns of malignant GCTs across primary sites and histologic subtypes using population-based database. Materials and Methods: Data were extracted from the Surveillance, Epidemiology, and End Results (SEER) program for patients diagnosed with malignant GCTs between 2010 and 2022. Cases were strati

SUBMITTER: Park HK 

PROVIDER: S-EPMC12654695 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature