Exploring the Scope of Functionalized <i>N</i>-Acylneuraminic Acid β-Methyl Glycosides as Inhibitors of <i>Neisseria meningitidis</i> CMP-Sialic Acid Synthetase.

ABSTRACT: Cell surface sialylation is utilized by a number of pathogenic bacteria to evade the host immune system through molecular mimicry of host sialoglycoconjugates. Human pathogen Neisseria meningitidis serotype B (NmB) expresses both sialylated capsule and surface lipooligosaccharides as pivotal virulence factors. An essential enzyme in the sialylation pathway of NmB is CMP-sialic acid synthetase (CSS), which produces the activated nucleotide sugar necessary for sialic acid transfer. In this work, novel C-4, -5, -7, and -9 functionalized derivatives of neuraminic acid β-methyl glycoside (Neuβ2Me) were synthesized as candidate CSS inhibitors. A number of these were found to reduce the activity of NmB CSS in vitro. The highest inhibition of NmB CSS, in a mixed

SUBMITTER: Chopra P 

PROVIDER: S-EPMC12654856 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature