The impact of adherence on colorectal cancer screening cost-effectiveness: A modeling study.

ABSTRACT:

Background

Adherence to colorectal cancer (CRC) screening remains suboptimal in many countries, reducing its cost-effectiveness. This study aimed to evaluate how multistage uptake rates influence the health benefit and cost-effectiveness of various CRC screening strategies in the Chinese population, incorporating both traditional and emerging screening methods.

Methods and findings

We developed a multistate Markov model (CRC-SIM) to evaluate the impact of multistep uptake on CRC screening. A hypothetical cohort of 100,000 individuals aged 40 was simulated and followed until 79 or death. Two-step screening strategies were modeled: initial screening followed by colonoscopy after a positive result. Traditional initial screening methods include: questionnaire-based risk assessme

SUBMITTER: Xie J 

PROVIDER: S-EPMC12654882 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature