Whole Genome Sequencing and Comparative Genomics of the Emerging Pathogen <i>Burkholderia pseudomallei</i> Isolated from Two Travel-Related Infections in Hungary.

ABSTRACT:

Background

Burkholderia pseudomallei, the causative agent of melioidosis, is a neglected tropical pathogen that has been increasingly encountered in Europe through travel-related infections. Clinical manifestations range from localized abscesses to life-threatening sepsis, posing diagnostic challenges in non-endemic regions.

Methods

We report two travel-associated melioidosis cases confirmed in Hungary between 2008 and 2024. Whole-genome sequencing (WGS), multilocus sequence typing (MLST), and core-genome MLST (cgMLST) were performed for molecular characterization. In parallel, a systematic review of travel-related melioidosis cases reported in Europe (1980-2025) was conducted according to PRISMA 2020 guidelines. Data were retrieved from PubMed, Scopus, Google Scholar

SUBMITTER: Henczko J 

PROVIDER: S-EPMC12654974 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature