Mitochondrial Network Fragmentation Leads to Dysfunction of Macrophages During <i>Echinococcus multilocularis</i> Protoscoleces Infection.

ABSTRACT: Alveolar echinococcosis (AE) is a fatal foodborne parasitic disease caused by the larvae of Echinococcus multilocularis. The disease primarily affects the liver. Previous studies have found that Kupffer cells have an immune protective effect, but in the late stages of AE, they are associated with parasite immune escape. The present study analyzed the effects of Echinococcus multilocularis protoscoleces (PSCs) infection on the mitochondrial morphology and function of macrophages, as well as their phagocytic function and apoptosis. Infection with PSCs has been shown to result in the fragmentation of the macrophage mitochondrial network, the impairment of mitochondrial membrane potential, the elevation of mitochondrial reactive oxygen species, and the reduction in mitochondrial

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12654988 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature