Interaction Between <i>DRD2</i> rs1076560 Genotype and Stimulant Dependence on Impulsivity and Self-Reported ADHD Traits in Men.

ABSTRACT:

Background and objectives

The dopamine D2 receptor (DRD2) plays a central role in fronto-striatal circuits regulating cognitive control and reward processing. The rs1076560 polymorphism alters receptor isoform expression, potentially modifying impulsivity and vulnerability to stimulant use disorders. We examined gene-environment interactions between rs1076560 and stimulant dependence in relation to impulsivity, ADHD traits, and hedonic capacity.

Methods

A total of 517 men (235 stimulant-dependent, 282 controls) completed the Barratt Impulsiveness Scale (BIS-11), Adult ADHD Self-Report Scale (ASRS v1.1), and Snaith-Hamilton Pleasure Scale (SHAPS). Genotyping for rs1076560 was performed using real-time PCR, and two-way ANOVAs tested genotype-by-group effects.

Results

SUBMITTER: Lachowicz M 

PROVIDER: S-EPMC12655105 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature