Identification and Integrative Discovery of Anti-Inflammatory Compounds Isolated from <i>Eclipta prostrata</i> (L.) L. by Network Pharmacology, Molecular Docking, and In Vitro Evaluation.

ABSTRACT: Background/Objective: Eclipta prostrata (L.) L. is a traditional medicinal herb utilized throughout Asia that is widely used for hepatoprotective activity, wound healing, and blood cooling/bleeding disorders. This work aimed to identify bioactive constituents from E. prostrata collected in Vietnam, and clarify their anti-inflammatory capacity of the extract and active fraction. Method: Extraction and isolation of compounds from the extract of E. prostrata were performed. The extract, fractions, and isolated compounds were evaluated for inflammatory cytokines in LPS-stimulated RAW264.7 cells. Isolates showed inflammatory potential by in silico approaches. Results: Thirteen compounds, comprising a first isolated compound (diosmin), flav

SUBMITTER: Van Anh C 

PROVIDER: S-EPMC12655162 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature