Supramolecular Lipid Nanoparticles Based on Amine β-CD Host-Guest Lipids: Design, Mechanisms, and Biosafety.

ABSTRACT: Background/Objectives: Lipid nanoparticles (LNPs) have demonstrated notable clinical success as advanced drug delivery systems. However, the development of novel covalently bonded ionizable lipids faces substantial technical challenges, as their modification is difficult and they have a high molecular weight. To address this issue, we report the use of host-guest complexes in supramolecular chemistry as functional lipid motifs for constructing LNPs. Methods: Ionizable amine β-cyclodextrin (amine β-CD)-derived host-guest amphiphilic lipid molecules (HGLs) were designed for the construction of multi-stage assembly supramolecular LNPs (MSLNPs). The structure-function relationships and stability of MSLNPs were explored by screening eight types of amine β-CDs and varying the ratio

SUBMITTER: Lv P 

PROVIDER: S-EPMC12655198 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature