Generating and Modeling Virtual Patient Data from Published Population Pharmacokinetic Analyses: A Vancomycin Case Study.

ABSTRACT: Background/Objectives: In recent years, clinical pharmacometrics has become vital for drug development and clinical practice, particularly for predicting drug efficacy and safety. Population pharmacokinetic models are used for drugs for which therapeutic drug monitoring is recommended in clinical practice. Numerous population pharmacokinetic models have been developed for patients with similar clinical and demographic characteristics, resulting in reduced inter-individual variability. Despite the existence of diverse-population pharmacokinetic models, selecting an appropriate model for bedside use remains challenging. This study proposes a model-simulated model-based meta-analysis (M-cubed) to construct a unified model capable of accommodating a wide range of patient backgrounds.

SUBMITTER: Suzuki M 

PROVIDER: S-EPMC12655213 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature