Dual-Algorithm Integration Framework Reveals Qing-Wei-Zhi-Tong's Dual Mechanisms in Chronic Gastritis.

ABSTRACT: Background: Chronic gastritis (CG) involves gastric mucosal imbalance, with H. pylori (>90% cases), acid-pepsin imbalance, and bile reflux as druggable mechanisms. FDA-approved drugs show limited efficacy against antibiotic-resistant strains and fail to target undruggable pathways (e.g., inflammation, autoimmune atrophy). Traditional Chinese Medicine (TCM), particularly Qing-Wei-Zhi-Tong micro-pills (QWZT), offers multi-target advantages, though its mechanisms remain poorly understood. Methods: The dual-algorithm integration framework predicts QWZT's pharmacological effects to treat gastritis. For druggable processes (pathways targeted by existing drugs), the structure-target-pathway similarity algorithm quantifies QWZT similar activities to FDA drugs, validated by gas

SUBMITTER: Shu Z 

PROVIDER: S-EPMC12655216 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature