Leucine Protects Dry Powders for Inhalation Against Irreversible Moisture-Induced Aggregation.

ABSTRACT: Background: Pulmonary administration offers a promising route for certain biologics, particularly when treating respiratory diseases. Spray drying is widely employed to produce inhalable powders with the biologics incorporated in a stabilizing amorphous sugar. Hydrophobic amino acids such as leucine are frequently added to improve dispersibility. Objectives: While the aerodynamic benefits of leucine are well established, its influence on irreversible moisture-induced dry powder particle aggregation and protein stability during storage remains less evaluated. Methods: In this work, inulin-based powders with and without 4 wt-% leucine were spray dried and stored at 43%, 58%, 69%, and 75% relative humidity (RH) at 20 ± 2 °C. Results: Immediately after drying, both

SUBMITTER: Jansen EM 

PROVIDER: S-EPMC12655236 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature