The Effects of <i>Semen Ziziphi Spinosae</i> Extract on LPS-Induced Astrocyte Gene Expression and Metabolites.

ABSTRACT: Background/Objectives: Semen Ziziphi Spinosae (SZS), a medicinal and edible traditional Chinese herb, has been widely used to treat insomnia. As critical regulators of the central nervous system, astrocytes play a pivotal role in maintaining sleep homeostasis. However, the mechanisms by which SZS modulates astrocytic function to improve sleep remain unclear. Methods: In this study, we employed an integrated transcriptomics and metabolomics approach to investigate the protective effects of SZS extract against lipopolysaccharide (LPS)-induced inflammatory injury and metabolic dysfunction in astrocytes. Results: Transcriptomic analysis revealed that SZS ameliorates cellular damage (including apoptosis, autophagy, and cell cycle dysregulation) through a FOXO3

SUBMITTER: Ma J 

PROVIDER: S-EPMC12655257 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature