Long-Term Epidemiological Trends of Human Adenovirus Infection in South Korea: A Single-Center Study (2007-2024).

ABSTRACT: Human adenoviruses (HAdVs; genus Mastadenovirus, family Adenoviridae) are major etiologic agents of respiratory infections, exerting a disproportionately large impact on children. However, no long-term study to date has spanned pre- and post-pandemic periods in a Korean tertiary setting. Here, we retrospectively analyzed 23,284 nasopharyngeal swabs collected between 2007 and 2024 at a tertiary medical center in South Korea. Most specimens were obtained from inpatients and outpatients presenting with fever or respiratory symptoms for differential viral diagnosis. HAdV was detected using real-time PCR, and positivity rates were compared by year, season, and age group. Overall, 2043 tested positive for HAdV. Annual positivity peaked in 2010, 2013, and 2016, followed by a sharp d

SUBMITTER: Kim YJ 

PROVIDER: S-EPMC12655292 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature