Ergosterol-Enriched Liposomes with Post-Processing Modifications for Serpylli Herba Polyphenol Delivery: Physicochemical, Stability and Antioxidant Assessment.

ABSTRACT: Background/Objectives: In the present study, ergosterol, a novel natural and animal-free alternative sterol, was investigated, and its effects on liposomal properties were assessed. Importantly, ergosterol's fungal origin offers a sustainable substitute for cholesterol, aligning with current trends in natural and vegan-friendly formulations. Methods: This study explored the effect of ergosterol content (10 mol% vs. 20 mol%) on the encapsulation efficiency (EE), physical properties, morphology, antioxidant activity, lipid peroxidation, and storage stability of Serpylli herba extract-loaded liposomes. Results: Liposomes with 20 mol% ergosterol exhibited significantly higher EE (~81.0%) than those with 10 mol% (~75.6%), along with improved resistance to UV- and freeze-dry

SUBMITTER: Jovanovic AA 

PROVIDER: S-EPMC12655308 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature