Bioactive Aromatic Plant Extracts Modulate Metabolism and Inflammation in HeLa Cells.

ABSTRACT: Aromatic plants are rich sources of bioactive compounds with recognized therapeutic potential. This study investigated the phytochemical composition and biological activities of ethanolic extracts from four aromatic species-Thymus vulgaris L. (thyme), Rosmarinus officinalis L. (rosemary), Aloysia citrodora (lemon verbena), and Tanacetum balsamita L. (costmary)-using HeLa human cancer cells as a model. LC-MS analysis identified 28-44 metabolites per species, with phenolic compounds and terpenoids comprising 58-67% of total metabolites. Biological assays demonstrated concentration-dependent inhibition of HeLa cell metabolism down to 150 µg/mL, with rosemary displaying the strongest effects. LDH assays confirmed membrane disruption, most notably for lemon verbena (

SUBMITTER: Silva S 

PROVIDER: S-EPMC12655313 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature