Unveiling the Therapeutic Mechanisms of Chinese Herbs in Heart Failure: Integrating Network Pharmacology, Molecular Docking, and Simulation Analysis.

ABSTRACT: Background: Heart failure (HF) is a leading cause of mortality and represents the final stage of various cardiovascular disorders. Although traditional Chinese herbs have been extensively applied in HF treatment and their clinical efficacy has been investigated, the underlying molecular mechanisms remain insufficiently understood. To address this gap, systematic approaches are required to elucidate the therapeutic basis of herbal interventions. Methods: In this study, we systematically analyzed the bioactive compounds from seven traditional Chinese herbs, Baiguo (Ginkgo biloba), Chishao (Radix Paeoniae Rubra), Biba (Piper longum), Aidicha (Ilex latifolia), Bajiaolian (Dysosma spp.), Beiwuweizi (Sc

SUBMITTER: Ahmad B 

PROVIDER: S-EPMC12655320 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature