Purification of Lepidilines A, B, C, and D from <i>Lepidium meyenii</i> Walpers by Centrifugal Partition Chromatography Followed by Semi-Preparative HPLC and Preliminary Evaluation of Anticancer Activity Against Neuroblastoma Cell Lines.

ABSTRACT: Lepidium meyenii Walpers (syn. Lepidium peruvianum Chacon) has been cultivated for centuries in the Peruvian Andes as both a vegetable and a traditional medicine resource. Maca is classified as a superfood and is widely used as a dietary supplement, particularly noted for its potential to enhance endurance, fertility, and endocrine balance. In recent years, there has been a growing interest in the cytotoxic effects of lepidilines and their derivatives; however, these compounds have been less extensively studied due to challenges associated with their isolation. This study aims to establish optimal extraction conditions to enrich lepidiline content in the extracts and to propose an efficient isolation method for four lepidilines using a green purification technique known as Ce

SUBMITTER: Tarabasz D 

PROVIDER: S-EPMC12655379 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature