Structural Characterization and In Vitro Hypoglycemic Activity of a Polysaccharides Obtained from <i>Fructus arctii</i>.

ABSTRACT: In recent years, the number of diabetes patients worldwide has been increasing daily, and more than 700 million people are in a prediabetic state. Fructus arctii exhibits notable anti-diabetic activity, but its active components remain unclear. In this study, a polysaccharide (FAP-W) was extracted and characterized using UV, FTIR, HPLC, NMR, AFM, the Congo red test, and SEM. FAP-W has a molecular weight of 1.99 × 10⁴ Da and mainly consists of α-d-glucopyranosyl-(1→2)-[β-d-fructofuranosyl-(1→2)]₁₀-β-d-furanofructosyl units. Monosaccharide analysis revealed mannose, glucose, galactose, and arabinose in a 3.4:23.59:21.27:47.7 ratio. In insulin-resistant HepG2 cells, FAP-W significantly increased glucose consumption, enhanced glycogen content, and elevated HK and P

SUBMITTER: Gong P 

PROVIDER: S-EPMC12655392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature