Inhibitory Activity of Calcium and Sodium Ion Channels of Neurotoxic <i>Protoplaythoa variabilis</i> V-Shape Helical Peptide Analogs and Their Neuroprotective Effect In Vitro.

ABSTRACT: Background/Objectives: One of the neurotoxic components from the sea trumpet polyps, Protopalythoa variabilis (Cnidaria, Anthozoa), is a 26-residue, V-shape helical peptide (PpVα). Its synthetic versions, i.e., the linear, the single-disulfide-bonded analog, and the chimeric peptide with a 6-residue stretch of the N-terminal native homologous peptide covalently linked to the linear sequence, were investigated for their activity on ion channels responsible for cellular excitability and synaptic transmission. Methods: Molecular docking analyses and dynamic simulations focused on the ability of PpVα peptides to bind ion channels selectively through interaction with critical residues at their binding sites. Results: Electrophysiological studies using the patch clamp

SUBMITTER: Teixeira Dos Santos A 

PROVIDER: S-EPMC12655438 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature