The Role of HMB Supplementation in Enhancing the Effects of Resistance Training in Older Adults: A Systematic Review and Meta-Analysis on Muscle Quality, Body Composition, and Physical Function.

ABSTRACT:

Background/objectives

Resistance training (RT) is a key strategy to counteract age-related declines in muscle strength and physical function. β-hydroxy-β-methylbutyrate (HMB) has been proposed as a complementary supplement to enhance these adaptations. However, the additional effects of RT plus HMB (RT+HMB) compared with RT alone remain unclear. This systematic review and meta-analysis evaluated the effects of RT+HMB versus RT alone on body composition, muscle quality (MQ), and physical function in older adults.

Methods

Following PRISMA guidelines (PROSPERO: CRD420251144810), six databases (PubMed, Scopus, Cochrane Library, CINAHL, Web of Science, and ScienceDirect) were searched up to July 2025. Randomized controlled trials comparing RT+HMB with RT alone were included. Meth

SUBMITTER: Garcia-Alonso A 

PROVIDER: S-EPMC12655442 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature