Does CytoSorb Interfere with Immunosuppression? A Pharmacokinetic and Functional Evaluation.

ABSTRACT: Background/Objectives: Cytokine release during organ transplantation contributes to primary graft dysfunction and requires careful immunomodulation. CytoSorb, a hemoadsorption device developed to reduce circulating cytokine levels, is increasingly used in critically ill patients. However, its impact on concurrent immunosuppressive therapy remains unclear. Methods: In this ex vivo study, we investigated the adsorption of five immunosuppressants-cyclosporine A, tacrolimus, methylprednisolone, mycophenolic acid, and 6-mercaptopurine-using a scaled-down CytoSorb hemoadsorption circuit and compared results to chronic and acute dialysis. Additionally, a whole blood model was used to assess the functional impact of CytoSorb treatment on leukocyte activation, using LPS and anti-CD3 s

SUBMITTER: Harm S 

PROVIDER: S-EPMC12655457 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature