<i>Limosilactobacillus fermentum</i> IOB802 Protects Against Blue Light-Induced Retinopathy via Gut Microbiota Modulation.

ABSTRACT:

Background

Blue light-induced retinal photodamage represents a growing public health concern globally. Lactic acid bacteria and their bioactive metabolites represent a promising therapeutic strategy for mitigating such damage.

Methods

This study evaluated the protective efficacy of Limosilactobacillus fermentum IOB802 and Lactobacillus plantarum subsp. plantarum IOB602 against blue light-induced retinal injury using both in vitro and in vivo models.

Results

In ARPE-19 cells exposed to blue light, treatment with postbiotics from IOB802 and IOB602 significantly restored cell viability (p < 0.05), enhanced antioxidant enzyme activities (GSH-Px, SOD, and CAT, p < 0.05), and reduced inflammatory cytokine levels (IL-6, IL-1β, TNF-α, and VE

SUBMITTER: Liu C 

PROVIDER: S-EPMC12655542 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature