Microfluidic Design of Ultradeformable Liposomes for Advanced Skin Delivery of <i>Stellaria media</i> Phytocomplex.

ABSTRACT: Background/Objectives: Ultradeformable liposomes represent an established platform for topical delivery of antioxidant compounds, thanks to their structural flexibility and ability to enhance skin permeation, but standardized manufacturing protocols are still lacking. This study presents a microfluidic-based strategy for the scalable production of ultradeformable liposomes encapsulating Stellaria media extract, a polyphenol-rich phytocomplex with strong antioxidant activity. Methods: Liposomes were produced with a GMP-like microfluidic platform enabling fine control of formulation parameters and high reproducibility under conditions directly transferable to continuous manufacturing. Process optimization tested different total flow rates. Characterization included parti

SUBMITTER: Ciriolo L 

PROVIDER: S-EPMC12655562 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature