Grape Seed Flavanols Restore Peripheral Clock of White Adipose Tissue in Obese Rats Under Circadian Alterations.

ABSTRACT: Background: White adipose tissue (WAT) exhibits diurnal oscillations regulated by clock genes, which autonomously control its functionality. These rhythms are modulated by the central clock and external factors, such as light exposure and diet. Flavanols, phenolic compounds known for their beneficial metabolic effects, have been shown to modulate the expression of clock genes. This study explored the impact of flavanols on clock gene expression in WAT explants from lean and obese rats under changes in light/dark cycles. Methods: WAT explants were obtained from 24 Fischer rats fed a standard diet (STD) or cafeteria diet (CAF) for seven weeks. During the final week, rats were changed to short (6 h of light, L6) or long (18 h of light, L18) photoperiods. CAF-fed rats were also a

SUBMITTER: Garcia-Martinez-Salvador M 

PROVIDER: S-EPMC12655575 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature