<i>Lactobacillus</i>-Fermented <i>Centella asiatica</i> Extract Inhibits Airway Inflammation in Cigarette Smoke Extract/LPS-Induced Mice.

ABSTRACT: Centella asiatica, a widely used medicinal herb in Oriental and increasingly Western medicine, is applied for wound healing, dermatological disorders, and gastrointestinal illness. We investigated the effects of fermented C. asiatica extract (FCAE), prepared with Lactobacillus, on airway inflammation in a murine model of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke extract (CSE) and lipopolysaccharide (LPS). CSE/LPS stimulation caused marked immune cell infiltration in airways. FCAE (100 and 200 mg/kg) reduced neutrophils in the bronchoalveolar lavage fluid (BALF) by 26.03% and 70.11%, respectively, and decreased activated T cells and B cells in the lung, mediastinal lymph nodes, and Peyer's patches, while inhibiting collagen fibrosis. FCAE s

SUBMITTER: Sung YY 

PROVIDER: S-EPMC12655661 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature