Theranostic Verteporfin-Conjugated Upconversion Nanoparticles for Cancer Treatment.

ABSTRACT: Photodynamic therapy (PDT) is a highly selective, clinically approved, minimally invasive technique that effectively eliminates cancer cells. Its effectiveness is limited by poor light penetration into tissue and the hydrophobic nature of photosensitizers, highlighting the need for new approaches to treatment. Here, a theranostic upconversion nanoplatform, consisting of a NaYF₄:Yb,Er,Tm,Fe core and a NaHoF₄ shell codoped with Yb, Nd, Gd and Tb ions, was designed to enhance PDT outcomes by integrating multi-wavelength upconversion luminescence, T₂-weighted magnetic resonance imaging (MRI) and PDT. The synthesized core-shell upconversion nanoparticles (CS-UCNPs) were coated with new verteporfin (VP)-conjugated alendronate-terminated poly(N,N<

SUBMITTER: Shapoval O 

PROVIDER: S-EPMC12655723 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature