Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole ¹⁸F Probe Targeting α-Synuclein Aggregates.

ABSTRACT: Background/Objectives: The role of α-synuclein (α-syn) in the pathogenesis of Parkinson's disease (PD) or neurodegenerative diseases such as Lewy body dementia (LBD) and multiple system atrophy (MSA) is commonly accepted. Through different physiological dysfunctions, abnormal forms of α-syn are generated. These abnormal aggregates accumulate and alter pre- and postsynaptic transmission, in particular that of dopamine. Thus, the development of a diagnostic biomarker of synucleinopathies remains crucial and challenging. The development of an α-syn positron emission tomography (PET) radiopharmaceutical may be suitable to early diagnose and stratify patients, follow up disease progression, and evaluate future therapies. Methods: To develop a selective α-syn PET tracer, we synthes

SUBMITTER: Boiaryna L 

PROVIDER: S-EPMC12655733 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature