Cytotoxic Cytochalasans from Sponge-Derived <i>Aspergillus</i> sp. SCSIO 41044.

ABSTRACT: Two new cytochalasans (1-2), along with eight known ones (3-10) were isolated from sponge-derived Aspergillus sp. SCSIO 41044. The planar structures of 1-2 were elucidated through extensive spectroscopic analyses and their absolute configurations determined by modified Mosher's methods. Biological evaluation revealed that 5, 7, and 8 showed potent cytotoxicity against small cell lung cancers H446 and H1048, with IC₅₀ values ranging from 0.0441 to 1.61 μM.

SUBMITTER: Pang X 

PROVIDER: S-EPMC12655855 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature