The Role of the Collateral Circulation in Stable Angina: An Invasive Placebo-Controlled Study.

ABSTRACT:

Background

Little correlation exists between the burden of ischemia and severity of angina in patients with stable coronary artery disease. This placebo-controlled, n-of-1 study investigated the relationship between ischemia, the collateral circulation, and symptoms in stable coronary artery disease. Additionally, it explored the association between progressive collateral recruitment and ischemic preconditioning.

Methods

Fifty-one participants with severe single-vessel coronary artery disease and angina were recruited. Antianginal medications were stopped, and daily angina symptoms were documented using a dedicated smartphone application (ORBITA [Objective Randomized Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina] app) for 14 days before u

SUBMITTER: Rajkumar CA 

PROVIDER: S-EPMC12655870 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature